Peer-Reviewed Publications
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This page provides citations to peer-reviewed publications evaluating intraoperative lavage strategies using standardized, activity-based microbiologic endpoints at surgical closure.
Note on nomenclature:
Several of the publications listed below evaluate Bactisure®, which is the identical formulation to Simini Protect Lavage. The two products are chemically and functionally equivalent.
Publications are grouped by model type to reflect how intraoperative lavage strategies are commonly evaluated across laboratory, surgical, and clinical contexts.
Laboratory and in vitro studies
Hamad C, Sheppard W, Chun R, et al. Comparing the in vitro efficacy of commonly used surgical irrigants for the treatment of implant-associated infections.
Compares bacterial recovery following lavage across multiple irrigation solutions in implant-associated laboratory models.
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O’Donnell J, Wu M, Cochrane N, et al. Efficacy of common antiseptic solutions against clinically relevant planktonic microorganisms.
Evaluates bacterial reduction of planktonic organisms using standardized in vitro microbiologic assays.
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Implant-associated and biofilm models
Kia C, Cusano A, Messina J, et al. Effectiveness of topical adjuvants in reducing biofilm formation on orthopedic implants.
Assesses bacterial reduction in early biofilm-associated states on orthopedic implant materials.
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Seta J, Pawlitz P, Aboona F, et al. Removal of Staphylococcus aureus and biofilm from porous titanium implants.
Evaluates bacterial recovery from porous titanium surfaces following standardized lavage protocols.
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In vivo surgical models
Powell A, et al. Effect of commercially available wound irrigation solutions on uninfected host tissue in a murine model.
Examines tissue response and healing following intraoperative lavage in a controlled surgical model.
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Veterinary clinical studies
Forzisi I, Vezzoni L, Bozzerla M, Vezzoni A. Use of Simini Protect Lavage as an adjuvant in revision orthopedic surgery.
Describes intraoperative use of lavage as an adjunct in high-risk and revision veterinary orthopedic procedures.
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Human clinical studies (contextual)
Hunter G, et al. Clinical effectiveness of a biofilm-disrupting surgical lavage in revision arthroplasty.
Reports intraoperative bacterial sampling before and after lavage in revision joint arthroplasty cases.
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Next steps
- Review the Evidence Summary — Key findings across model types
- View the Evaluation Methodology
- Request a Clinical Evaluation Kit